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Macrophage is any of the specialized class of large, phagocytic cells within the tissues, including blood, that originate from specific white blood cells called monocytes and that destroy foreign bacteria and other microorganisms as well as cellular debris, and senescent and damaged cells. They are one of two main cells that defend the body against infection by ingesting invading microorganisms, the other being neutrophils.

Lyme disease or Lyme borreliosis is the most commonly reported vector-borne disease in the Northern Hemisphere. Caused by infection with the spirochetal (helical) bacteria Borrelia burgdorferi, Lyme disease is primarily transmitted to humans, as well as dogs, horses, and other domesticated animals, by the bite of infected ticks.